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To further complicate drug development and diagnosis those AD criteria behaviors denoting cognitive decline can also result from a number of other clinical conditions including vascular disease (44, 45), frontotemporal dementia, PD-induced dementia, HIV infection (46, 47), as well as cumulative oxidative damage and toxicities accompanying normal aging (48)

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Despite a substantial body of animal research — including studies on tendon healing, gastric ulcer repair, and neurological protection — no Phase III clinical trial has been completed, and no IND (Investigational New Drug) application has advanced to support an NDA filing as of March 2026