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The counteraction occurred against the severe additional intracranial hypertension (and against additionally increased portal and caval hypertension and aortal hypotension), centrally induced, since caused by additionally increased venous resistance/pressures, within the cranium (as shown by the highest venous hypertension additionally originated within the cranium, additional volume inside the sinus lumen)

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Unfortunately, these studies were not designed as large-scale, randomized controlled trials and thus the efficacy of high dose vitamin C therapy remains to be determined